134 articles - From Friday Sep 22 2023 to Friday Sep 29 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Gastroenterology |
|---|
AGA Clinical Practice Update on Risk Stratification for Colorectal Cancer Screening and Post-Polypectomy Surveillance: Expert Review. BEST PRACTICE ADVICE 8: The decision to continue post-polypectomy surveillance for individuals older than 75 years should be individualized, based on an assessment of risks, benefits, and comorbidities. BEST PRACTICE ADVICE 9: Risk-stratification tools for CRC screening and post-polypectomy surveillance that emerge from research should be examined for real-world effectiveness and cost-effectiveness in diverse populations (eg, by race, ethnicity, sex, and other sociodemographic factors associated with disparities in CRC outcomes) before widespread implementation. |
AGA Clinical Practice Update on the Epidemiology, Evaluation, and Management of Exocrine Pancreatic Insufficiency: Expert Review. BEST PRACTICE ADVICE 15: EPI should be monitored and baseline measurements of nutritional status should be obtained (body mass index, quality-of-life measure, and fat-soluble vitamin levels). A baseline dual-energy x-ray absorptiometry scan should be obtained and repeated every 1-2 years. |
| Gut |
British Society of Gastroenterology guidelines for the diagnosis and management of cholangiocarcinoma. Quality of evidence is presented using the Appraisal of Guidelines for Research and Evaluation (AGREE II) format. The recommendations arising are to be used as guidance rather than as a strict protocol-based reference, as the management of patients with CCA is often complex and always requires individual patient-centred considerations. |
UK and Ireland Joint Advisory Group (JAG) consensus statements for training and certification in diagnostic endoscopic ultrasound (EUS). An evidence-based certification pathway has been commissioned by JAG to support and quality assure EUS training. This will form the basis to improve quality of training and safety standards in EUS in the UK and Ireland. |
Updates to the modern diagnosis of GERD: Lyon consensus 2.0. Criteria that have not performed well in the diagnosis of actionable GERD have been retired. Personalisation of investigation and management to each patient's unique presentation will optimise GERD diagnosis and management. |
| Hepatology |
National prevalence estimates for steatotic liver disease and Sub-Classifications using consensus nomenclature. Our findings highlight the utility of the new consensus nomenclature to address deficiencies present with the old nomenclature, and identify areas that require research to further refine classifications of SLD. |
meta-analyses and systematic reviews
| Clin Gastroenterol Hepatol |
|---|
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
Antibiotic use as a risk factor for irritable bowel syndrome: Results from a nationwide, case-control study. Compared to none, 1-2 (OR 1.67, 95% CI 1.61-1.73) and =3 antibiotics dispensations (OR 3.36, 95% CI 3.24-3.49) were associated with increased odds of IBS (p for trend <0.001) regardless of the antibiotic class. Prior antibiotics use was associated with an increased odds of IBS with the highest risk among people with multiple antibiotics dispensations. |
Randomised clinical trial: Efficacy and safety of on-demand vonoprazan versus placebo for non-erosive reflux disease. On-demand vonoprazan may be a potential alternative to continued daily acid suppression therapy for the relief of episodic heartburn in patients with NERD. NCT04799158. |
| Am J Gastroenterol |
A Study of Dietary Patterns Derived by Cluster Analysis and their Association with Nonalcoholic Fatty Liver Disease Severity among Hispanic Patients. Given the importance of sociocultural influences on diet, it is important to understand dietary patterns prevalent among Hispanic patients with NAFLD. Using cluster analysis, we identified one plant-based versus a distinct fast-food/meat-based pattern associated with detrimental effects among our population. This information is an important starting point for tailoring dietary interventions for Hispanic patients with NAFLD. |
Conventional vs short duration of antibiotics in patients with moderate or severe cholangitis: Non-inferiority randomized trial. Short duration of antibiotics is non-inferior to conventional duration in patients with moderate to severe cholangitis in terms of clinical cure, recurrence of cholangitis and overall mortality. |
Double-blind multicenter randomized clinical trial comparing glucagon vs placebo in the resolution of alimentary esophageal impaction. Glucagon is no more effective than placebo in resolving EFBI or shortening the time required to remove the foreign body. (EUDRA-CT number 2019-004920-40). |
Effects of GLP-1 and Other Gut Hormone Receptors on the Gastrointestinal Tract and Implications in Clinical Practice. Multiple studies reviewed in this article document the diverse effects of these drugs on the GLP-1 receptors that are widely expressed in the human body, including the nervous system modulating appetite, the gastrointestinal tract modifying gastric emptying, and lipid metabolism regulation leading to reduction in fat deposition. The objective of this review is to summarize the mechanism of action of incretin receptor agonists, their effects in the gastrointestinal tract, and implications in clinical practice, particularly in the practice of gastroenterology, endoscopy, and surgery. |
Optimizing the management algorithm for adults with functional constipation failing a fiber/laxative trial in general gastroenterology: Cost-effectiveness and cost-minimization analysis. Anorectal function testing appears to be an emergent technology to optimize cost-effective outcomes, overcoming testing costs by phenotyping care. |
Osteoporosis and fragility fractures in patients with cirrhosis evaluated for liver transplantation: Identification of high-risk patients based on computed tomography at evaluation. In cirrhotic patients evaluated for LT, CT scan identified persons with severe osteoporosis without additional costs. |
Poor subjective sleep quality predicts symptoms in Irritable Bowel Syndrome using the Experience Sampling Method. Poor subjective sleep quality was associated with higher next day lower GI symptom levels, but not vice versa. Objective sleep measures did not predict next day abdominal symptoms, potentially supporting the conclusion that it is the perception of sleep quality which is most influential. This study may be used to guide future research into the effect of sleep interventions on GI symptoms. |
Prognostic value of the modified Rutgeerts' score for long-term outcomes after primary ileocecal resection in Crohn's disease. The increasing mRS corresponds closely with the risk for surgical and clinical recurrence. An index mRS = i2b is associated with surgical recurrence, an index mRS = i1 is associated with clinical recurrence and i1 or i2b with progression to severe endoscopic recurrence. These results support tight monitoring of disease activity and treatment optimization in patients with ileal lesions, and a more conservative management in patients with anastomotic lesions. |
Utility of the Serum-Based Endoscopic Healing Index in Monitoring Therapeutic Response in Ulcerative Colitis. EHI values are significantly responsive to changes in mucosal inflammation, also in UC patients, and can confirm and/or rule out mucosal inflammation with an almost similar accuracy to that of faecal calprotectin. |
| Clin Gastroenterol Hepatol |
An analysis of delayed bleeding in cases of colorectal endoscopic submucosal dissection due to types of direct oral anticoagulants in Japan. Dabigatran was associated with a higher DBR than other DOACs, and only rivaroxaban was associated with a significantly lower DBR than warfarin. |
Long-term Safety Outcomes of Fecal Microbiota Transplantation: Real-World Data over Eight Years from the Hong Kong FMT Registry. This prospective real-world data from Asia's first FMT registry demonstrated that FMT has an excellent long-term safety profile. The risk of developing new medical conditions beyond 12 months after FMT is low. |
Sex differences in treatment response to nucleos(t)ide therapy in chronic hepatitis B: a multicenter longitudinal study. Sex differences exist for treatment outcomes among hepatitis B patients. Male sex associated with 16% higher likelihood of clinical remission and 31% higher likelihood of biochemical response than females, while viral suppression and HCC incidence were similar between the two groups. |
The Index of Severity for Eosinophilic Esophagitis (I-SEE) Reflects Longitudinal Clinicopathologic Changes in Children. I-SEE is a responsive severity metric in children treated long-term during routine clinical care. Baseline low BMI and poor feeding were more common in children with severe I-SEE scores. |
The diagnostic performance of fecal immunochemical tests for detecting advanced neoplasia at surveillance colonoscopy. The use of FIT prior to surveillance colonoscopy provides clinicians with insights into the risk of AN. This raises the possibility of a method to triage individuals, facilitating the more efficient management of endoscopic resources. |
Vedolizumab, Adalimumab, and Methotrexate Combination Therapy in Crohn's Disease (EXPLORER). Combination therapy resulted in endoscopic and clinical remission at week 26 in 34.5% and 54.5% of patients, respectively, with no safety signal related to the treatment regimen. This supports further evaluation of combination therapy in CD. number NCT02764762. |
| Endosc Int Open |
Endoscopically placed fiducial markers for image-guided radiotherapy in preoperative gastric cancer: Technical feasibility and potential benefit. Endoscopic placement of fiducial markers in the stomach is technically feasible and safe. Being well visible and positionally stable, markers provide a potential benefit for IGRT. |
Performance of endoscopic submucosal dissection for undifferentiated early gastric cancer: a multicenter retrospective cohort. ESD could be considered as the initial step to manage UD-EGC, providing at least an "entire-lesion" biopsy to guide therapeutic strategy. When histology confirms absence of lymphovascular and perineural invasion, this modality could be therapeutic, providing low recurrence rates. |
| Endoscopy |
Forced cold snare polypectomy is related to cold snare defect protrusions and incomplete polyp resections: A prospective observational study. There is the possibility that FCSP is associated with the occurrence of CSDPs and IPR. Further studies are necessary in the future to confirm our results. |
| Gastroenterology |
HBV DNA AND HBSAG LEVELS AT 24 WEEKS OFF-TREATMENT PREDICT CLINICAL RELAPSE AND HBSAG LOSS IN HBEAG NEGATIVE PATIENTS WHO DISCONTINUED ANTIVIRAL THERAPY. Among HBeAg negative CHB patients who discontinued antiviral therapy and who did not experience clinical relapse before FU W24, serum levels of HBV DNA and HBsAg at FU W24 can be used to predict subsequent clinical relapse and HBsAg clearance. A combination of HBsAg <100 IU/mL with HBV DNA <100 IU/mL identifies patients with a low risk of relapse and excellent chances of HBsAg loss, and could potentially be used as an early surrogate endpoint for studies aiming at finite therapy in HBV. |
p21 prevents the exhaustion of CD4+ T cells within the antitumor immune response against colorectal cancer. Our data reveal the importance of p21 in controlling cell cycle and preventing exhaustion of Th1 cells. Furthermore, we unveil the therapeutic potential of CDK inhibitors such as Palbociclib to reduce T cell exhaustion for future treatment of patients with colorectal cancer. |
| Gastrointest Endosc |
| Gut |
Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis. FTO downregulation promoted UC by decreasing CerS6 expression, leading to increased S1P accumulation in IECs and aggravating colitis via m 6 A-dependent mechanisms. Lower FTO expression in UC patients may enhance their response to vedolizumab treatment. |
Immunosuppressive CD29+ Treg accumulation in the liver in mice on checkpoint inhibitor therapy. We identified IL2 as a critical modulator of both CD29+ and CD29- hepatic Tregs, but expansion of the liver Treg population with aPD-1 driven by CD29+ Tregs was in part IL2-independent. We propose that CD29+ Tregs constitute a unique subpopulation of hepatic Tregs that are primed to respond to ICI agents and mediate resistance. |
Interplay between diet, circulating indolepropionate concentrations and cardiometabolic health in US populations. Specific microbial species and dietary fibre jointly predicted significantly higher circulating IPA concentrations at higher tryptophan intake. Dietary and plasma tryptophan, as well as its kynurenine pathway metabolites, demonstrated divergent associations from those for IPA, which was significantly predictive of lower risk of T2D. |
Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. The RPLS signature could be a novel metric of chemotherapy outcome in iCCA. Further development and validation of this transcriptomic signature is warranted to develop precision chemotherapy strategies in these settings. |
Precancerous nature of intestinal metaplasia with increased chance of conversion and accelerated DNA methylation. Chromatin immunoprecipitation sequencing for H3K27ac and single-cell assay for transposase-accessible chromatin by sequencing were conducted using IM mucosa. expression. |
Shorter-acting glucagon-like peptide-1 receptor agonists are associated with increased development of gastro-oesophageal reflux disease and its complications in patients with type 2 diabetes mellitus: a population-level retrospective matched cohort study. Starting shorter-acting GLP-1 RAs is associated with increased risks of GERD and its complications. |
| Hepatology |
Physiologic changes in the hepatopulmonary syndrome before and after liver transplant: A longitudinal and predictor analysis. We present the largest and longest longitudinal data analysis in HPS. In addition to rates of physiological decline and improvement before and after liver transplantation, we present novel predictors of PaO2 decline and improvement rates. Our findings enhance understanding of the natural history of HPS and provide pathophysiologic clues. Importantly, they may assist providers in prognostication and prioritization before and after transplant. |
Spatial proteomics of immune microenvironment in nonalcoholic steatohepatitis-associated hepatocellular carcinoma. Our work provides the first detailed spatial map of single-cell phenotypes and multicellular connections in NASH-HCC. We demonstrate that interactions between MDSCs and TAMs with effector T cells underlie immunosuppression in NASH-HCC and are an actionable target. |
| J Hepatol |
PAGE-B incorporating moderate HBV DNA levels predicts risk of HCC among patients entering into HBeAg-positive chronic hepatitis B. With a scoring range from 0 to 12 points, a PAGED-B score differentiates the HCC risk. A PAGED-B score significantly differentiates the 5-year HCC risk: low <7 points and high =7 points. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
Review article: The complex interplay between diet and Escherichia coli in inflammatory bowel disease. coli and other Proteobacteria interact with certain dietary components to promote gut inflammation. Well-designed clinical trials are required before dietary recommendations for disease management can be made. |
| Clin Gastroenterol Hepatol |
Development and Current State of Digital Therapeutics for Irritable Bowel Syndrome. BGBTs are effective, guideline-recommended treatments for IBS. Digital therapeutic devices offer accessible, cost-effective treatment options for delivery of adjunctive BGBT for the treatment of IBS. The decision to recommend digital BGBTs should be guided by careful patient assessment that includes mental health screening and risk assessment. |
| Gastroenterology |
Pathobionts in IBD: Origins, Underlying Mechanisms, and Implications for Clinical Care. Despite recognizing that pathobionts likely contribute to the pathogenesis of IBD, more work is needed to define their modes of action. Determining whether causal relationships exist between pathobionts and specific disease characteristics could pave the way for improved care for patients, particularly for those not responding to current IBD therapies. |
| Gastrointest Endosc |
| Gut |
Smart capsules for sensing and sampling the gut: status, challenges and prospects. As a compliment to gut sensing smart capsules, significant amount of effort has been put into the development of robotic capsules to collect tissue biopsy and gut microbiota samples to perform in-depth analysis after capsule retrieval which will be a game changer for gut health diagnosis, and this advancement is also covered in this review. The expansion of smart capsules to robotic capsules for gut microbiota collection has opened new avenues for research with a great promise to revolutionise human health diagnosis, monitoring and intervention. |
| J Hepatol |
Bioactive signaling lipids as drivers of chronic liver diseases. These diseases include alcohol associated liver disease (AALD), non-alcoholic fatty liver disease (NAFLD), viral hepatitis and hepatocellular carcinoma (HCC). We discuss the balance between pathogenic and beneficial bioactive lipids as well as potential therapeutic targets related to the agonism or the antagonism of their receptors. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Clin Gastroenterol Hepatol |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |